I’ve cardiovascular problems, arthritis and osteoporosis, and the pain I feel is horrible. I decided to ask a naturist and he recommend me to use the Active Botanical CO. Therapeutic Formulation – 12,000mg Tincture. It recommends me to begin with a 25mg/day doses but then duplicate after 3 weeks of usage. I’ve feel much more relief than my normal capsules I take for the pain, also improved me on the sleeping, even though it changed my appetite a little bit.